Alterações radiográficas de coluna cervical em artrite reumatoide / Radiographic changes of cervical spine in rheumatoid arthritis

INTRODUÇÃO: O envolvimento da coluna cervical é comum na artrite reumatoide (AR). OBJETIVO: Estudar a prevalência das alterações radiológicas de coluna cervical em pacientes com AR e sua associação com perfil clinico e sorológico da doença. MÉTODOS: Analisaram-se as radiografias de coluna cervical em perfil neutro hiperextensão, hiperflexão e transoral de 80 pacientes com AR para presença de subluxação atlanto-axial (LAA), invaginação basilar (IB) e instabilidade subaxial (ISA). Dados de perfil demográfico, clínico (nódulos, pneumonite intersticial, síndrome Sjögren secundária, uso de medicamentos etc.) e sorológico (FR, anti-CCP e FAN) foram obtidos por revisão de prontuários. RESULTADOS: Havia alguma alteração de eixo de coluna cervical em 26/80 (32,5%); em 12/80 (15%) havia LAA; em 6/80(7,5%) existia IB; em 13/80 (16,2%) existia ISA. Erosões em odontoide foram vistas 16/80 (20,0%). As alterações do eixo cervical estavam associadas com idade de início da doença e duração da mesma (P = 0,03 e 0,02, respectivamente). Não se encontrou associação das alterações em coluna cervical com raça, gênero, nódulos, pneumonite intersticial, Sjögren secundário, FR, FAN ou anti-CCP. Pacientes com alterações do eixo cervical apresentavam mais erosões de odontoide (P = 0,03). CONCLUSÕES: Alterações radiológicas em eixo de coluna cervical são comuns e aparecem mais frequentemente em indivíduos com diagnóstico mais precoce de AR e maior tempo de doença.

INTRODUCTION: The involvement of the cervical spine is a common feature of rheumatoid arthritis (RA). OBJECTIVE: To study the prevalence of radiographic changes of the cervical spine in patients with RA and their association with clinical and serological profiles of the disease. METHODS: We analysed lateral (neutral position, hyperextension, hyperflexion) and transoral views of cervical spine radiographs from 80 individuals with RA to investigate the presence of atlanto-axial subluxation (AAS), basilar invagination (BI), and subaxial instability (SAI). Demographic, clinical (nodules, interstitial pneumonitis, secondary Sjögren's syndrome, medications etc.), and serologic (rheumatoid factor - RF, cyclic citrullinated peptide antibody - anti-CCP, and antinuclear factor - ANF) data were obtained from the clinical records. RESULTS: Cervical spine misalignments were identified in 26/80 (32.5%) participants; AAS occurred in 12/80 (15%) participants, BI in 6/80 (7.5%), and SAI in 13/80 (32.5%). Odontoid erosions were identified in 16/80 (20.0%) participants. Cervical spine misalignment exhibited associations with age at onset and disease duration (P = 0.03 and 0.02, respectively). No associations were identified between the cervical spine changes and the participants' ethnicity or gender, presence of nodules, interstitial pneumonitis, secondary Sjögren's syndrome, RF, ANF, or anti-CCP. The participants with cervical spine misalignment exhibited higher frequencies of odontoid erosion (P = 0.03). CONCLUSIONS: Cervical spine misalignment was a common radiographic finding and occurred more frequently in participants with earlier onset and longer length of RA.

Resultado en el tratamiento quirúrgico de la inestabilidad atlantoaxoidea / Results of the surgical treatment of atlantoaxial instability

Introducción: La inestabilidad de la columna cervical es el aumento en la movilidad más allá de los límites fisiológicos de una vértebra sobre otra en alguno de sus ejes, que condiciona síntomas en el paciente. Existen causas traumáticas, degenerativas, metabólicas y neoplásicas. Material y métodos: Se realizó estudio retrospectivo, longitudinal, observacional y descriptivo, de intervención deliberada, en pacientes con cirugía por inestabilidad atlantoaxoidea, de enero de 1993 a mayo de 2002, con un seguimiento mínimo de cinco años. Resultados: Se evaluaron 11 pacientes, con edades de 25 a 75 años, media de 56 años. El sexo predominante fue el femenino. La etiología fue iatrogénica en seis casos, cuatro por artritis reumatoide y uno postraumática. En todos se realizó fijación y artrodesis occipitocervical con resección del arco posterior. El déficit neurológico preoperatorio predominante según la escala de Ranawat fue grado II, y en el posoperatorio fue grado I. Conclusiones: La edad media de nuestra serie fue discretamente menor respecto a la indicada en la literatura; el sexo predominante correspondió a lo informado en la literatura. Existió mejoría en ocho de los 11 pacientes, como en otras series. La mayor incidencia se observó entre los 30 y 64 años. La actividad ocupacional con mayor frecuencia fue la del hogar. El déficit neurológico según la escala de Ranawat mejoró en 72 % de los pacientes.

BACKGROUND: Instability of the cervical spine is defined as an increase in flexibility farther than the physiological limits of one vertebra over another in some of its axes, conditioning symptoms for the patient. Traumatic, degenerative, metabolic and neoplastic causes have all been identified. METHODS: A retrospective, longitudinal, observational and descriptive study was carried out on patients surgically intervened specifically for atlantoaxial instability from January 1993 to May 2002, with a minimum 5-year follow-up. RESULTS: Eleven patients were evaluated. Ages ranged from 25 to 75 years (average age 56 years) with a female predominance. Etiology was iatrogenic in six cases, and there were four cases of rheumatoid arthritis and one case due to trauma. In all cases, fixation was accomplished with occipitocervical arthrodesis with posterior arch resection. Predominant preoperative neurologic deficit according to Ranawat was grade II and postoperatively was grade I. CONCLUSIONS: The average age of patients in our series was discreetly lower in regard to what has been reported in the literature. Female predominance was in accordance with previous publications. Eight of 11 patients showed improvement as in other series. A higher impact was observed in patients between 30 and 64 years of age. The occupational activity with the highest frequency was homemaker, and the neurologic deficit according to Ranawat showed improvement in 72% of the patients.